Antabuse enhances the symptoms of drunkenness in about 10-15 minutes after alcohol consumption. During the Antabuse course, severe withdrawal symptoms can be observed about 1 hour after the consumption of alcoholic beverages. Antabuse Online - Alcohol Problems Antabuse enhances the symptoms of drunkenness in about 10-15 minutes after alcohol consumption. During the Antabuse course, severe withdrawal symptoms can be observed about 1 hour after the consumption of alcoholic beverages. buy zoloft